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KMID : 0921620230530010001
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Journal of Bacteriology and Virology
2023 Volume.53 No. 1 p.1 ~ p.10
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Plazomicin?a New Aminoglycoside?for Treating Complicated Urinary Tract Infections
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Mohammad Saydur Rahman
Gazi Mohammad Al Amin
Shah Mohammad Anwar
Mohammad Ferdaus Azam
Fatema Akhter
Mohammad Rabiul Islam
Koh Young-Sang
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Abstract
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Plazomicin belongs to a new class of semisynthetic aminoglycosides that suppress bacterial protein synthesis. The US Food and Drug Administration has approved this antibacterial drug for use in adult patients with complicated urinary tract infections (cUTIs), such as pyelonephritis. The worldwide emergence of multidrug- resistant (MDR) organisms has become a significant health issue. It is a promising alternative to carbapenems or β-lactam/β-lactamase inhibitors for treating cUTIs caused by MDR Enterobacterales. Plazomicin is primarily designed to overcome the common resistance mechanisms of pathogens. It has also demonstrated good in vitro efficacy against various resistant gram-negative pathogens. Plazomicin inhibits bacterial protein synthesis and exhibits rapid bactericidal efficacy against numerous extended-spectrum beta-lactamase (ESBL) producing, aminoglycoside- resistant, and carbapenem-resistant bacterial isolates. Similar to other amin- oglycosides, plazomicin inhibits bacterial protein synthesis by attaching to the 30S ribosomal subunit of bacteria. Plazomicin also demonstrated a favorable minimum inhibitory concentration value compared to other aminoglycosides such as gentamicin, amikacin, and tobramycin. The commonly observed adverse effects of plazomicin include headache, hypertension, nausea, diarrhea, vomiting, and hypotension. In this review, we discuss the likelihood of using plazomicin to treat bacterial infections, focusing on its chemistry, mode of action pharmacokinetics, indications for treatment, adverse reactions, and safety profile.
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KEYWORD
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Plazomicin, Antibiotics, Aminoglycosides
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